A 10 hour journey with 3 small children aged 5 and under need not be a nightmare. My tips:

Pack snacks
Have the electronics charged and headphones at hand
Frequent stops
Lots of silly song singing
Pick out clouds and describe what they look like
Do not try to stay on your diet, road trips = Skittles and Pringles
Diapers and spare clothes within reach, not in a bag
Empty trash bag for soiled clothes, vomiting and … trash
Coffee stops for Momma and Dad (we are talking Venti)
The promise of a large glass of pinot noir at the destination! Happy trails.